Abstract
We report the case of a healthy donor who was mobilized for the purpose of performing an unrelated donor transplantation with subcutaneous injections of rhG-CSF. Because of accidental loss of progenitors, 3 days after completing the first collection, the donor was mobilized again with rhG-CSF, and progenitors were collected. While a similar increase in the pre-apheresis leukocyte count was observed in both procedures, fewer mononuclear cells were mobilized during the second rhG-CSF course, resulting in a poor CD34+ yield. These data suggest that an 8-day interval between commencement of rhG-CSF mobilizations is insufficient to predict an efficient collection of hematopoietic progenitors to ensure engraftment after bone marrow transplantation. Bone Marrow Transplantation (2000) 26, 351–352.
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MLL is a Fundación Séneca Fellow.
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Vallejo, C., Lozano, M., Ortuño, F. et al. Re-mobilization of peripheral blood progenitor cells within a short time interval fails to achieve effective progenitor cell yields. Bone Marrow Transplant 26, 351–352 (2000). https://doi.org/10.1038/sj.bmt.1702515
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DOI: https://doi.org/10.1038/sj.bmt.1702515
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