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Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor

Abstract

We describe a healthy peripheral blood stem cell (PBSC) donor who developed a cutaneous reaction, erythema exsudativum multiforme, during the administration of granulocyte colony-stimulating factor (G-CSF) for mobilization. The cutaneous lesions were located on his hips, apart from the site of G-CSF injection. Treatment with topical corticosteroid was commenced, and the lesions resolved completely within a week. Adverse cutaneous reactions induced by G-CSF have been reported infrequently in healthy donors. Further documentation of cases and their full evaluation will be of great importance for both physicians and PBSC donor. Bone Marrow Transplantation (2000) 26, 239–240.

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References

  1. Murata M, Harada M, Kato S et al. Peripheral blood stem cell mobilization and apheresis: analysis of adverse events in 94 normal donors Bone Marrow Transplant 1999 24: 1065–1071

    Article  CAS  Google Scholar 

  2. Anderlini P, Donato M, Chan K-W et al. Allogeneic blood progenitor cell collection in normal donors after mobilization with filgrastim: the MD Anderson Cancer Center experience Transfusion 1999 39: 555–560

    Article  CAS  Google Scholar 

  3. Anderlini P, Przepiorka D, Champlin R, Korbling M . Biologic and clinical effects of granulocyte colony-stimulating factor in normal individuals Blood 1996 88: 2819–2825

    CAS  PubMed  Google Scholar 

  4. Paul C, Giachetti S, Pinquier L et al. Cutaneous effects of granulocyte colony-stimulating factor in healthy volunteers Arch Dermatol 1998 134: 111–112

    Article  CAS  Google Scholar 

  5. Sato N, Sawada K, Takahashi T et al. A time course study for optimal harvest of peripheral blood progenitor cells by granulocyte colony-stimulating factor in healthy volunteers Exp Hematol 1994 22: 973–978

    CAS  PubMed  Google Scholar 

  6. Samlaska CP, Noyes DK . Localized cutaneous reactions to granulocyte colony-stimulating factor Arch Dermatol 1993 129: 645–646

    Article  CAS  Google Scholar 

  7. Asnis LA, Gaspari AA . Cutaneous reactions to recombinant cytokine therapy J Am Acad Dermatol 1995 33: 393–410

    Article  CAS  Google Scholar 

  8. Takagi S, Ohsaka A, Taguchi H et al. Pyoderma gangrenosum following cytosine arabinoside, aclarubicin and granulocyte colony-stimulating factor combination therapy in myelodysplastic syndrome Int Med 1998 37: 316–319

    Article  CAS  Google Scholar 

  9. Sasaki O, Yokoyama A, Uemura S et al. Drug eruption caused by recombinant human G-CSF Int Med 1994 33: 641–643

    Article  CAS  Google Scholar 

  10. Glass LF, Fotopoulos T, Messina JL . A generalized cutaneous reaction induced by granulocyte colony-stimulating factor J Am Acad Dermatol 1996 34: 455–459

    Article  CAS  Google Scholar 

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Mori, T., Sato, N., Watanabe, R. et al. Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor. Bone Marrow Transplant 26, 239–240 (2000). https://doi.org/10.1038/sj.bmt.1702501

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