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Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation

Bone Marrow Transplantation volume 26, pages 109–111 (2000)Cite this article

Abstract

Tacrolimus is increasingly used for graft-versus-host disease (GVHD) prophylaxis and therapy in the allogeneic stem cell transplant (allo-SCT) setting. Pancreatitis, previously described as a side-effect of cyclosporine, has not been reported in allo-SCT recipients receiving tacrolimus. We present here a case of acute pancreatitis in a 28-year-old patient with chronic myelogenous leukemia (CML) who received an unrelated umbilical cord blood transplant (UCBT) and tacrolimus for GVHD prophylaxis. On day +31 post-transplant, she developed severe acute pancreatitis with multiorgan failure, from which she recovered completely. Tacrolimus was the probable cause of pancreatitis in this patient. Bone Marrow Transplantation (2000) 26, 109–111.

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Authors and Affiliations

  1. University of Colorado Bone Marrow Transplant Program, Denver, CO, USA

    Y Nieto, SI Bearman, PJ Cagnoni, RB Jones & EJ Shpall

  2. Radiology Department, Denver, CO, USA

    P Russ

  3. Gastroenterology Department, Denver, CO, USA

    G Everson

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  1. Y Nieto
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  2. P Russ
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  3. G Everson
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  4. SI Bearman
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  5. PJ Cagnoni
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  6. RB Jones
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  7. EJ Shpall
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Nieto, Y., Russ, P., Everson, G. et al. Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. Bone Marrow Transplant 26, 109–111 (2000). https://doi.org/10.1038/sj.bmt.1702471

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  • DOI: https://doi.org/10.1038/sj.bmt.1702471

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