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Successful treatment of human herpesvirus-6 encephalitis after bone marrow transplantation

Bone Marrow Transplantation volume 24, pages 1245–1248 (1999)Cite this article

Abstract

We report two cases of human herpesvirus-6 (HHV-6)-associated encephalitis in patients after BMT. Both patients reported distinct neurological symptoms with disorientation, sleepiness and loss of short-term memory. Diagnosis was based on PCR analysis of the cerebrospinal fluid (CSF) positive for HHV-6 variant B-DNA. After institution of therapy with foscarnet in both cases, neurological symptoms improved and in one patient clearance of HHV-6-DNA from CSF was demonstrated. These cases show that HHV-6 infection has to be considered in patients with neurological symptoms following BMT and effective treatment of HHV-6 encephalitis is possible if instituted early.

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Authors and Affiliations

  1. Department of Hematology/Oncology/Immunology and Rheumatology, University of Tübingen, Germany

    W Bethge, L Kanz & H Einsele

  2. Department of Medical Virology, University of Tübingen, Germany

    R Beck & G Jahn

  3. Department of Neuroradiology, University of Tübingen, Germany

    P Mundinger

Authors
  1. W Bethge
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  2. R Beck
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  3. G Jahn
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  4. P Mundinger
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  5. L Kanz
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  6. H Einsele
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Bethge, W., Beck, R., Jahn, G. et al. Successful treatment of human herpesvirus-6 encephalitis after bone marrow transplantation. Bone Marrow Transplant 24, 1245–1248 (1999). https://doi.org/10.1038/sj.bmt.1702065

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  • DOI: https://doi.org/10.1038/sj.bmt.1702065

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