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Clinical features and successful recovery from disseminated nocardiosis after BMT

Bone Marrow Transplantation volume 19, pages 81–82 (1997)Cite this article

Abstract

Nocardiosis has rarely been described after BMT. When the doses of immunosuppressive therapy were tapered, a 46-year-old BMT recipient developed chronic graft-versus-host disease (GVHD) and immunosuppressive drugs were increased. Sixteen days later the patient developed nocardiosis diagnosed by lung biopsy. Trimethoprim/sulfamethoxazole (TMP/SMZ) was initiated but the doses were reduced because of rising creatinine levels. Skin and cerebral dissemination of nocardiosis was observed and TMP/SMZ doses were increased. After 4 months, the brain lesion was unaltered despite resolution of pulmonary lesions. Clinical improvement was observed after drainage of the brain abscess.

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Authors and Affiliations

  1. The BMT Program, Fundação Pró Sangue Hemocentro de São Paulo and Discipline of Hematology, University of São Paulo Medical School, Brazil

    CM Machado, MC Macedo, M Ostronoff, AC Silva, E Zambon, C Massumoto, DF Chamone & FL Dulley

  2. INCOR-HC Department of Pathology, University of São Paulo Medical School, Brazil

    JB Castelli

Authors
  1. CM Machado
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  2. MC Macedo
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  3. JB Castelli
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  4. M Ostronoff
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  5. AC Silva
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  6. E Zambon
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  7. C Massumoto
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  8. DF Chamone
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  9. FL Dulley
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Cite this article

Machado, C., Macedo, M., Castelli, J. et al. Clinical features and successful recovery from disseminated nocardiosis after BMT. Bone Marrow Transplant 19, 81–82 (1997). https://doi.org/10.1038/sj.bmt.1700616

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  • DOI: https://doi.org/10.1038/sj.bmt.1700616

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