Abstract
IN an earlier publication1, results obtained by inserting certain steroids directly into tied-off segments of the uterine horns of spayed rabbits were reported. It was found that several steroids which on systemic administration have a progestational effect in the rabbit do not have such activity when inserted into the uterus. It was suggested that steroids of this type exert a progestational effect by an indirect mechanism, becoming converted in the body either into progesterone or one of the related steroids which have direct progestational activity.
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Höhn, E. O., and Robson, J. M., J. Physiol., 111, 174 (1950).
Robson, J. M., and Sharaf, A. A., J. Physiol. (in the press).
Hooker, C. W., and Forbes, T. R., Endocrinol., 45, 71 (1949).
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HÖHN, E. Steroids exerting a Direct Progestational Effect on the Rabbit Endometrium. Nature 169, 844 (1952). https://doi.org/10.1038/169844a0
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DOI: https://doi.org/10.1038/169844a0
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