Storage of Stilbamidine in the Animal Body

Abstract

EARLIER work^1–4 on stilbamidine (trans-4:4′-diamidinostilbene) had led to the conclusion that extensive retention and storage for prolonged periods must almost certainly occur after injection into the animal body; but the difficulties likely to be encountered in extracting the drug from body tissue, and estimating it, had rather deterred one from attempting to prove that prolonged storage does occur, and to determine the principal sites of storage. However, advantage has recently been taken of an opportunity of working on this subject, and substantial progress has been made in solving the preliminary aspects of the problem of determining site or sites of storage, and the effect of such storage upon fat and mineral metabolism, in an attempt to explain the delayed toxic action of the drug and of the product of its photochemical dimerization.