Abstract
Two years ago, a report was published1 by us of some aspects of the pharmacology of morphine. It described what we consider to be a very remarkable example of drug antagonism. Dogs narcotized to the point of unconsciousness with morphine or (more usually) a mixture of morphine (10 mgm./kgm.) and hyoscine (0.6 mgm./kgm.) can be brought to a state of complete and intelligent wakefulness within two minutes of the intravenous injection of the analeptic drug. Since then, we have continued investigating this phenomenon, and have regularly observed this arousal after the injection of a wide series of drugs, including a number not mentioned in the earlier paper.
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References
Shaw, F. H., and Bentley, G., Med. J. Aust., 868 (1949).
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SHAW, F., BENTLEY, G. Morphine Antagonism. Nature 169, 712–713 (1952). https://doi.org/10.1038/169712a0
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DOI: https://doi.org/10.1038/169712a0
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