Abstract
CARBOXYPEPTIDASE can split from peptide chains those terminal amino-acids that carry a free α-carboxyl group. The enzyme was used by Grassman et al.1 in demonstrating that the C-terminal residue of glutathione is glycine, and by Lens2 in studying the C-terminal residues of the peptide chains of insulin. Lens found that alanine is the end-group in two of the four chains of insulin, but was unable to identify the end-groups of the other two chains.
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References
Grassman, W., Dycherhoff, H., and Eibeler, H., Z. phys. Chem., 189, 112 (1930).
Lens, J., Biochim. et Biophys. Acta, 3, 367 (1949).
Fraenkel-Conrat, H., et al., J. Amer. Chem. Soc., 73, 625 (1951).
Green, F. C., and Shroeder, W. A., J. Amer. Chem. Soc., 73, 1385 (1951).
Thompson, A. R., Nature, 168, 390 (1951).
Work, E., Biochem. J., 42, xlix (1948).
Fisher, R. B., Parsons, D. S., and Morrison, G. A., Nature, 161, 764 (1948).
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THOMPSON, A. The C-Terminal Residue of Lysozyme. Nature 169, 495–496 (1952). https://doi.org/10.1038/169495a0
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DOI: https://doi.org/10.1038/169495a0
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