Abstract
THE reaction between streptomycin and diacetyl seems not to have been reported in the literature. When mixed with diacetyl in aqueous alkaline solution, this antibiotic produces a pink colour by virtue of its guanidine groupings, the reaction being of the type first described by Voges and Proskauer1, and investigated by several other workers2.
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References
Voges, O., and Proskauer, B., Z. Hyg. Inf., 28, 20 (1898).
Harden, A., and Norris, Dorothy, J. Physiol., 42, 332 (1911). Lang, K., Z. physiol. Chem., 208, 273 (1932).
Barritt, M. M., J. Path. Bact., 42, 441 (1936). Eggleton, P., Elsden, S. R., and Gough, Mary, Biochem. J., 37, 526 (1943).
Boxer, G. E., and Jelinek, V. C., J. Biol. Chem., 170, 491 (1947).
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HALLIDAY, W. A New Colour Reaction of Streptomycin. Nature 169, 335–336 (1952). https://doi.org/10.1038/169335b0
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DOI: https://doi.org/10.1038/169335b0
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