Abstract
IT has been found that very low concentrations (0.5 µgm./ml.) of methylene blue inhibit the growth in vitro of Bact. tularense. This inhibition is of the same order of magnitude as that caused by the most potent antibiotics1. The dye had, however, no effect in vivo; doses of 0.5 gm. each, applied intraperitoneally for three successive days, did not protect mice infected even with low doses (1–10 LD50) of the bacterium.
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YANIV, H., AVI-DOR, J. In vitro Inhibition of Bacterium tularense by Methylene Blue. Nature 169, 201 (1952). https://doi.org/10.1038/169201a0
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DOI: https://doi.org/10.1038/169201a0
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