Abstract
IN the course of a general investigation into the influence of vitamin D on the phospholipid metabolism in rats, we found indications of an independent synthesis of the phospholipids in bone marrow in some of our experimental animals. In a number of animals the values of the specific activity (expressed as the percentage of the injected dose per mgm. phosphorus per 100-gm. rat) of the phospholipid fraction isolated from the femur and the tibia within two hours after subcutaneous injection of phosphorus-32 as phosphate exceeded values found for the phospholipid fraction isolated from the plasma. The phenomenon presented itself so often and so clearly that it could not be ascribed to the inaccuracy inherent to the analytical methods used.
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References
Zilversmit, D. B., Entenman, C., and Fishler, M. C., J. Gen. Physiol., 26, 325 (1943).
Zilversmit, D. B., Entenman, C., and Chaikoff, I. L., J. Biol. Chem., 176, 193 (1948).
Chaikoff, I. L., et al., J. Biol. Chem., 141, 809 (1941); 144, 59 (1942); 145, 281 (1942).
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CLAASSEN, V., VOGELS, R. & WÖSTMANN, B. An Independent Synthesis of Phospholipids in the Femur and Tibia of White Rats. Nature 169, 191–192 (1952). https://doi.org/10.1038/169191a0
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DOI: https://doi.org/10.1038/169191a0
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