Abstract
IT has been known for some time that di-iso-fluorophosphonate and similar drugs, which are anti-cholinesterases in nature, in toxic doses produce syndromes resembling certain psychoses, and that in schizophrenics they aggravate signs and symptoms1. Conversely, it was thought that cholinesterase and other drugs counteracting acetylcholine should reduce the manifestations of schizophrenia, and they have done so, on injection into the cerebral ventricles of man2.
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SHERWOOD, S., RIDLEY, E. & McCULLOCH, W. Effects of Intraventricular Acetylcholine, Cholinesterase, and Related Compounds in Normal and ‘Catatonic’ Cats. Nature 169, 157 (1952). https://doi.org/10.1038/169157a0
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DOI: https://doi.org/10.1038/169157a0
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