Abstract
TRICHOTHECIN was the name given by Freeman and Morrison1 to a stable antifungal agent produced by Trichothecium roseum. They report the ability of this antibiotic to withstand boiling, and it has been found here that its activity is unaffected by autoclaving for 1 hr. at 20 lb./sq. in. pressure on three successive occasions. This marked thermostability and the neutral reaction of trichothecin have prompted its use in this laboratory for studies on antibiotic production in the soil; Fusarium oxysporum var. cubense was the test fungus used and the lethal dose 90 was adopted as the activity unit.
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References
Freeman, G. G., and Morrison, R. I., Nature, 162, 30 (1948).
Pollock, M. R., Symposium of Soc. for Exp. Biol., 3, 193 (1949).
Kodicek, E., Symposium of Soc. for Exp. Biol., 3, 217 (1949).
Rept. Proc. 7th Internat. Bot. Congr. Stockholm, 1950 (still in typescript).
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HESSAYON, D. ‘Double-Action’ of Trichothecin and its Production in Soil. Nature 168, 998–999 (1951). https://doi.org/10.1038/168998b0
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DOI: https://doi.org/10.1038/168998b0
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