Abstract
IT is the general practice among virologists to use 10 per cent normal serum saline as the diluent of choice for the preparation of virus emulsions. In keeping with this practice, horse-sickness vaccine consists essentially of suitably prepared emulsions of selected virus strains in 10 per cent normal horse serum diluted in the same fluid to contain per dose an adequate number of infecting doses of these strains. Since the efficacy of the vaccine is dependent entirely upon the injection of living virus, it is essential that the diluting fluid should be one which favours longevity of the virus. Of a number of media tried, the 10 per cent horse serum saline was found to be the most desirable (Alexander, personal communication).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
POLSON, A., DENT, J., LAWRENCE, S. et al. An Improved Diluent for the Production of African Horse-sickness Virus Vaccine. Nature 168, 655–656 (1951). https://doi.org/10.1038/168655a0
Issue Date:
DOI: https://doi.org/10.1038/168655a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.