Abstract
ONE of the agents most effective in causing regression of tumours is the polysaccharide which Shear and his associates were able, some years ago, to extract from the bacterium Serratia marcescens1. This polysaccharide causes a high percentage of regression in the tumours of mice, but unfortunately it is rather toxic for human beings. If more were known as to the exact nature of the polysaccharide, it might be possible to find other compounds similar in their action on tumours, but less toxic.
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References
Shear, M. J., and Turner, F. C., J. Nat. Cancer Inst., 4, 81 (1943). Hartwell, J. L., Shear, M. J., and Adams, J. R., ibid., 4, 107 (1943).
Heilbrunn, L. V., and Wilson, W. L., Proc. Soc. Exp. Biol. and Med., 70, 179 (1949).
Heilbrunn, L. V., and Wilson, W. L., Science, 112, 56 (1950); Protoplasma, 39, 389 (1950).
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MOST, S. Effect of Shear's Polysaccharide on Plasma Clotting. Nature 168, 342–343 (1951). https://doi.org/10.1038/168342a0
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DOI: https://doi.org/10.1038/168342a0
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