Abstract
IN a recent series of papers, Pauling, Corey and Branson1 and Pauling and Corey2a-g have proposed structures for synthetic polypeptides and proteins based on helical configurations of the molecules, and have claimed that these account for the X-ray results of Bamford, Hanby and Happey3 on the polypeptides, and for the X-ray photographs of a number of proteins. It is the purpose of this communication to indicate that, in fact, the unit cells of Pauling and Corey are unsatisfactory for at least two of the three polypeptides which have been studied in detail, and probably also for α-keratin. Comments on the structures of Pauling and Corey, and these authors' objections to the αII-fold, will be reserved for a later paper from these Laboratories.
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References
Pauling, Corey and Branson, Proc. U.S. Nat. Acad. Sci., 37, 205 (1951).
(a) Pauling and Corey, Proc. U.S. Nat. Acad. Sci., 37, 235 (1951); (b) ibid., 241; (c) ibid., 251; (d) ibid., 256; (e), ibid., 261; (f) ibid., 272; (g) ibid., 282.
Bamford, Hanby and Happey, Proc. Roy. Soc., A, 205, 30 (1951).
Bamford, Hanby and Happey, Proc. Roy. Soc., A, 206, 407 (1951).
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BAMFORD, C., HANBY, W. Structure of Synthetic Polypeptides and Proteins. Nature 168, 340–341 (1951). https://doi.org/10.1038/168340b0
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DOI: https://doi.org/10.1038/168340b0
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