Abstract
IN 1948, Stone reported that infection by influenza viruses of embryonated hens' eggs after allantoic inoculation1, and of mouse lungs after intranasal instillation2, could be prevented by pretreatment of the exposed cells with the receptor-destroying enzyme of Vibrio choleræ3. It seems worth adding to these observations the finding that death of mice from infection by a neurotropic variant of influenza virus, neuro-WS4, can be similarly prevented by pretreatment of the mice with an intracerebral injection of receptor-destroying enzyme, and that the return of susceptibility to infection, following a single inoculation of receptor-destroying enzyme, runs roughly parallel to the return of inhibitory activity of the brain5 to influenza virus hæmagglutination.
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CAIRNS, H. Protection by Receptor-destroying Enzyme against Infection with a Neurotropic Variant of Influenza Virus. Nature 168, 335 (1951). https://doi.org/10.1038/168335a0
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DOI: https://doi.org/10.1038/168335a0
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Zellatmung und Virusenzym
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