Abstract
ALTHOUGH rhodanine (I) has some fungicidal activity1, it was found to be ineffective as a mildewor rot-preventing agent on cotton cloth. Through condensation of rhodanine with aldehydes and ketones, derivatives (II) having marked mildew-proofing activity may be obtained. More than a hundred such derivatives have been prepared and tested in our laboratory. It is interesting to note that the new mildew-proofing agents contain the structure present in many plant fungicides (tetramethylthiuram disulphide and the salts of dithiocarbamic acid), as well as a carbonyl group conjugated with an ethylenic linkage, found in another class of fungicides2.
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References
U.S. Patent 1,962,109.
Geiger and Conn, J. Amer. Chem. Soc., 67, 112 (1945).
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BROWN, F., BRADSHER, C. Mildew-preventing Activity of Rhodanine Derivatives. Nature 168, 171 (1951). https://doi.org/10.1038/168171b0
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DOI: https://doi.org/10.1038/168171b0
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