Abstract
Gans and Miley1 showed that skeletal muscle of the adrenalectomized animal is easily fatigued in situ. Ingle2 used this property of the adrenalectomized rat as a basis for the assay of cortical hormones, and he has more recently shown3 that cortisone also increases its resistance to fatigue. Schweitzer4 attributed this readiness to fatigue to a fall in blood pressure due to the loss of the adrenals. The fatigue has also been attributed in part to impaired neuromuscular transmission5, but Walker6 opposes this view.
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References
Gans, H. M., and Miley, H. H., Amer. J. Physiol., 82, 1 (1927).
Ingle, D. J., Endocrin., 34, 191 (1944).
Ingle, D. J., J. Clin. Endocrin., 10, 1312 (1950).
Schweitzer, A., J. Physiol., 104, 21 (1945).
Hartmann, F. A., and Lockwood, J. E., Proc. Soc. Exp. Biol. and Med., 29, 141 (1931).
Walker, S. M., Amer. J. Physiol., 149, 7 (1947).
Ramey, E., Goldstein, M. S., and Levine, R., Amer. J. Physiol., 162, 10 (1950).
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D'SILVA, J., NICOL, D. Response of the Isolated Rat Diaphragm to Repeated Stimulation. Nature 168, 1125–1126 (1951). https://doi.org/10.1038/1681125b0
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DOI: https://doi.org/10.1038/1681125b0
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