Abstract
IN the course of a study of the non-protein activator(s)1 of blood coagulation, which always occur(s) in the cephalin fraction of the phospholipids, without being identical with the classical cephalins, two inhibitors of the first stage of the clotting process, namely, glutamic acid and sphingosine, were discovered by means of paper chromatography. Both compounds are completely ineffective in the second stage of the clotting process.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fischer, A., and Hecht, E., Biochem. Z., 269, 115 (1934).
Chargaff, E., Levine, C., and Green, Ch., J. Biol. Chem., 175, 67 (1948).
Tocantins, L. M., Carroll, R. T., and McBride, Th. J., Proc. Soc. Exp. Biol. Med., 68, 110 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HECHT, E. New Inhibitors of the First Stage of the Blood-clotting Process. Nature 167, 279–280 (1951). https://doi.org/10.1038/167279b0
Issue Date:
DOI: https://doi.org/10.1038/167279b0
This article is cited by
-
Die Bedeutung des plasmatischen Gerinnungssystems in der Fr�hphase arterieller Thrombusbildung
Klinische Wochenschrift (1979)
-
Hämophilie, Mangelzustand oder Überschuß eines Hemmkörpers?
Klinische Wochenschrift (1966)
-
Wechselwirkungen zwischen fördernden und hemmenden Substanzen der Blutgerinnung
Experientia (1954)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.