Abstract
BARIUM carbonate, used as an adsorbent for stable (platelet-free), oxalated, horse plasma (shaking with 10 mgm./ml. for 30 min. at 0° C.) removes prothrombin with an undialysable, thermolabile substance, destroyed by heating to 60° C. for 30 min. This substance, apparently an albumin, when added to non-activated plasma (without addition of brain thromboplastin), acts as an inhibitor of plasma coagulation.
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FIALA, S. A Thermolabile Inhibitor of Plasma Coagulation. Nature 167, 279 (1951). https://doi.org/10.1038/167279a0
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DOI: https://doi.org/10.1038/167279a0
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