Abstract
FEW observations have been recorded on the action of œstrogens on the reticulo-endothelial system, and there is considerable disagreement concerning their action upon the histiocytes. Fluhmann, working with the rabbit1, and Nicol with the guinea pig2, showed that injection of œstrogenic hormones stimulated the appearance and activity of phagocytic cells in the endometrium of the uterus, as evidenced by the capacity of the cells to take up trypan blue. This was associated with growth and enlargement of the uterus. They considered these cells to belong to the reticulo-endothelial system. Nicol believed they were derived partly via the blood stream and partly from the connective tissue of the endometrium, and that the activity of these cells in some manner prepared the endometrium for the subsequent action of the luteal hormone. Fluhmann regarded these cells as scavengers.
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NICOL, T., HELMY, I. Influence of Œstrogenic Hormones on the Reticulo-Endothelial System in the Guinea Pig. Nature 167, 199–200 (1951). https://doi.org/10.1038/167199b0
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DOI: https://doi.org/10.1038/167199b0
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