Abstract
HOMOGENATES of rats' livers, and aqueous extracts of acetone powders of rats' livers, have been found to convert riboflavin into a flavin chromatographically different from riboflavin, flavin mononucleotide, and flavin adenine dinucleotide. The amount formed increases with time, and the conversion is accelerated by rise in temperature, but does not occur after heating at 100° C. The reaction is therefore thought to be enzymic. The flavin cannot be detected in unincubated homogenates which have been concentrated many times by Crammer's1 method for extracting flavins.
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References
Crammer, J. L., Nature, 161, 349 (1948).
Warburg, O., and Christian, W., Biochem. Z., 298, 150 (1938).
Emmerie, A., Rec. Trav. chim., 58, 290 (1939). Bessey, O. A., Lowry, O. H., and Love, R. H., J. Biol. Chem., 180, 755 (1949).
Sanadi, D. R., and Huennekens, F. M., 117th Meeting of the American Chemical Society, Abstracts of Papers, P. 60c (1950).
Pallares, E. S., and Garza, H. M., Arch. Biochem., 22, 63 (1949).
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WHITBY, L. Enzymic Formation of a New Riboflavin Derivative. Nature 166, 479–480 (1950). https://doi.org/10.1038/166479b0
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DOI: https://doi.org/10.1038/166479b0
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