Abstract
IN the study of respiratory infection it is important to determine the extent to which an aerosol is retained and the distribution of the retained particles. Retention has been studied, usually with inhomogeneous aerosols of particle-density well in excess of unity, particularly in relation to pneumoconiosis1; and viable counts of retained organisms have been made2. Difficulties arise in viable counts: disintegration of the head of, for example, a guinea pig and plating out of the resultant slurry is an unsatisfactory procedure, and naturally occurring organisms interfere. (We have found about 10,000 heat-resistant spores in normal guinea pig lungs.)
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BUCKLAND, F., HARPER, G. & MORTON, J. Use of Spores Labelled with Radiophosphorus in the Study of the Respiratory Retention of Aerosols. Nature 166, 354–355 (1950). https://doi.org/10.1038/166354a0
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DOI: https://doi.org/10.1038/166354a0
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