Abstract
BACTERIA possess their own enzymes and can synthesize to a greater or less degree all the substances which are necessary for their growth ; in consequence, pathogenic forms have a metabolism which is distinct from that of their host, while nearly all bacteria can be grown in vitro in the absence of living cells. Viruses are often considered to represent a degenerative simplification of this condition in which the enzymic equipment, although tacitly assumed to be present, is defective to such an extent that a dependence upon host metabolism has developed which deprives the virus of the capacity for independent growth. While this may perhaps be the case in the hickettsiæ, which fall outside the scope of this article, a consideration of the available literature leaves one with the impression that there is little, if any, definite evidence that the true viruses have any enzyme activity at all, while their multiplication may well be more closely related to the mechanisms of heredity than to the growth of bacteria, being secured by some form of control over the metabolism of the host which recalls the control of the activities of the cytoplasm by genes and organisers.
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Bauer, D. Multiplication of the Animal Viruses. Nature 164, 767–771 (1949). https://doi.org/10.1038/164767a0
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DOI: https://doi.org/10.1038/164767a0
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