Abstract
THE extension of the Michaelis–Menten theory to a mixture of two substrates and an enzyme which attacks both given by Thorn1 has also been worked out by us and appears in a publication now in the press2. We have given a method of obtaining the ratio of the Michaelis constants which is simpler than his. Using Thorn's symbols, his last equation but one simplifies to where Vm is the maximum initial velocity of the mixed substrates. This equation can be transformed into, the equation
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References
Thorn, M. B., Nature, 164, 27 (1949).
Adams, D. H., and Whittaker, V. P., Biochim. et Biophys. Acta (in the press).
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WHITTAKER, V., ADAMS, D. A Method for Determining the Ratio of the Michael is Constants of an Enzyme with Respect to Two Substrates. Nature 164, 315–316 (1949). https://doi.org/10.1038/164315a0
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DOI: https://doi.org/10.1038/164315a0
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