Abstract
H. Cullumbine and M. Simpson1 have reported the results of their investigations on the activity of several derivatives of thymine (5-methyl-uracil) having an antithyroid property and a stimulating action on the bone marrow. These researches were based on the assumption that if thymine, according to Spiess, Jacobson and Williams, possesses a therapeutic value in the treatment of pernicious anæmia, its thio-derivatives should have a similar property with the simultaneoús antithyroid activity. It is known that one of the greatest disadvantages of antithyroid drugs now being used is their toxic effect on the functioning of the bone marrow. The quantitative changes of reticulocytes and leucocytes in normal and splenectomized rabbits after a parenteral treatment with the compounds being tested were the basis of Cullumbine and Simpson's investigations.
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References
Cullumbine, H., and Simpson, M., Nature, 159, 680 (1947).
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JURAND, A. Effect of 5-Alkyl (Benzyl) Derivatives of 2-Thio-4-Methyl-Uracil on the Thyroid Gland and the Bone Marrow in Rabbits. Nature 162, 896 (1948). https://doi.org/10.1038/162896a0
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DOI: https://doi.org/10.1038/162896a0
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