Abstract
Smith and Hale1 were the first to point out that coagulation by staphylococci takes place in two stages. First, the bacterial product is converted to a thrombin-like agent by an activator substance found in plasma. This thrombin-like agent then produces fibrin. Gerheim, Ferguson and Travis2, and Kaplan and Spink3 have pointed out that the activator substance is associated with the albumin fraction in ammonium sulphate fractionation, while the latter workers showed that in alcoholic fractionation the activator appears to be associated with the alpha and beta globulins. Kaplan and Spink also have made an important contribution in their studies on the inhibition of the staphylocoagulase reaction.
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References
Smith, W., and Hale, J. H., Brit. J. Exp. Path., 25, 101 (1944).
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Lack, C. H., Nature, 161, 559 (1948).
Gerheim, E. B., Ferguson, J. H., and Travis, B. L., Fed. Proc., 7, 41 (1948).
Gerheim, E. B., Ferguson, J. H., Travis, B. L., Johnston, C. L., and Boyles, P. W., Proc. Soc. Exp. Biol. and Med. (in the press).
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GERHEIM, E. Staphlococcal Coagulation and Fibrinolysis. Nature 162, 732 (1948). https://doi.org/10.1038/162732a0
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DOI: https://doi.org/10.1038/162732a0
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