Abstract
DESCRIBING the histological demonstration of mucin after periodic acid, McManus1 states that a positive reaction is given, inter alia, by "certain pituitary cells" and "the colloid of the pituitary stalk". According to Chow2, the follicle-stimulating and luteinizing fractions of the anterior pituitary secretion are glycoproteins, and Evans et al.3 confirm that the former contains 10·3–13·1 per cent carbohydrate and 8 per cent glucosamine. According to K. Meyer‘s classification, it is thus a mucoprotein, that is, it contains more than 4 per cent hexosamine. Furthermore, Gurin4 has shown that chorionic gonadotropin is also a mucoprotein, containing galactose (10–12 per cent) and hexosamine (5–6 per cent) as an integral part of its molecule, and Gey et al.5 have demonstrated the production of this hormone by cytotrophoblast cells in tissue culture. On the contrary, Fraenkel-Conrat et al.6 have shown that the growth-hormone fraction of the pituitary contains only 0·25 per cent sugar and less than 0·9 per cent glucosamine.
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References
McManus, J. F. A., Nature, 158, 202 (1946).
Chow, B. F., "Advances in Protein Chemistry", 1, 153 (1944).
Evans, Fraenkel-Conrat, Simpson and Li, Science, 89, 249 (1939).
Gurin, S., Proc. Soc. Exp. Biol. Med., 49, 48 (1942).
Gey, Hellman and Seegar, Science, 88, 306 (1938).
Fraenkel-Conrat, Meamber, Simpson and Evans, Endocrinology, 27, 605 (1940).
Hotchkiss, R. D., Arch. Biochem., 16, 131 (1948).
Severinghaus, A., "Cytology of the Pituitary Gland" (Williams and Wilkins, Baltimore, 1938).
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PEARSE, A. Cytochemistry of the Gonadotropic Hormones. Nature 162, 651 (1948). https://doi.org/10.1038/162651a0
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DOI: https://doi.org/10.1038/162651a0
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