Abstract
RECENT investigations have shown that the sympathomimetic activity present in several organs and in large amounts in adrenergic nerves, for example, the splenic nerves of cattle, is chiefly due to lævo-noradrenalin or l-arterenol, which has been identified by quantitative biological and colorimetric tests (Euler1,2). By using the cat‘s blood pressure in conjunction with the fowl‘s rectal cæcum (Barsoum and Gaddum3) as test preparations, showing activity ratios for l-adrenalin and l-noradrenalin of 1 : 2–4 and 20–30 : 1 respectively, adrenalin has been detected in extracts of spleen, and splenic nerves, in amounts corresponding to 1–4 per cent of that of noradrenalin.
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References
von Euler, U. S., Acta Physiol. Scand., 12, 73 (1946).
von Euler, U. S., Acta Physiol. Scand. (in the press).
Barsoum, G. S., and Gaddum, J. H., J. Physiol., 85, 1 (1935).
Shaw, F. H., Biochem. J., 32, 19 (1938).
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EULER, U. Assay of norAdrenalin and Adrenalin in Extracts of Nerves and Tissues. Nature 162, 570–571 (1948). https://doi.org/10.1038/162570b0
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DOI: https://doi.org/10.1038/162570b0
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