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Pharmacological Activities in Different Rodent Species of d-Tubocurarine Chloride and the Dimethyl Ether of d-Tubocurarine Iodide

Nature volume 161, pages 817–819 (1948)Cite this article

Abstract

THE molecule of d-tubocurarine chloride contains two phenolic hydroxy groups as well as two methoxy groups attached to the aromatic nucleus1. The hydroxy groups can be alkylated ; when they are methylated, the resulting dimethyl ether differs in a striking way from d-tubocurarine chloride in its pharmacological properties2.

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References

  • King, H., J. Chem. Soc, 1157 (1939).

  • Dutcher, J. D., J. Amer. Chem. Soc, 68, 419 (1946).

    Article  CAS  Google Scholar 

  • Raventós, J., private communication, to be published elsewhere.

  • Chou, T. C., Brit. J. Pharmacol., 2, 1 (1947).

    CAS  PubMed  Google Scholar 

  • Miller, L. C., and Tainter, M. L., Proc. Soc. Exp. Biol. Med., 57, 261 (1944).

    Article  CAS  Google Scholar 

  • McIntyre, A. R., "Curare, its History, Nature and Clinical Use", 154 (Chicago, 1947).

    Google Scholar 

  • Brazil, O. V., Seba, R. A., and Campos, J. S., Bol. Inst. Vital. Brazil, 5, 79 (1945) (through Chem. Abstr., 41, 3872 ; 1947).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Pharmacological Laboratory,

    H. O. J. COLLIER & SHEILA K. PARIS

  2. Research Laboratory, Allen and Hanburys, Ltd., Ware

    L. I. WOOLF

Authors
  1. H. O. J. COLLIER
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  2. SHEILA K. PARIS
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  3. L. I. WOOLF
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COLLIER, H., PARIS, S. & WOOLF, L. Pharmacological Activities in Different Rodent Species of d-Tubocurarine Chloride and the Dimethyl Ether of d-Tubocurarine Iodide. Nature 161, 817–819 (1948). https://doi.org/10.1038/161817a0

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