Abstract
ŒSTROGENIC substances are usually extracted from the urine of pregnant women, pregnant mares or stallions with organic solvents not miscible in water. There are certain disadvantages inherent in this method: large extraction vessels are required ; in view of the great bulk of the initial liquid containing the strogenic substances in low concentration and the relatively small total interface between the urine and the solvent, a relatively large volume of the latter has to be used ; this in turn involves the use of a large distillation apparatus and a high fuel consumption for the evaporation of the solvent from the extract. Moreover, a high proportion of ballast substances which later require separation accompanies the Œstrogenic substances in the extract.
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SULMAN, F. Preparation of Œstrogens from Urine by Application of High Temperatures. Nature 161, 605 (1948). https://doi.org/10.1038/161605a0
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DOI: https://doi.org/10.1038/161605a0
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