Abstract
In 1944 Albanese, Frankston and Irby1 published their hydrogen peroxide – perchloric acid oxidation method for the estimation of methionine in protein hydrolysates and human urine. They stated: “… the applicability of the procedure to the urine was established by means of a study which demonstrated that the normal urinary constituents failed to react as methionine. This practice was further justified by the observations that the ingestion of dl-methionine by normal individuals resulted in a prompt elevation of the methionine level in the urine, as determined by our method. From a limited series of observations, it has been found that the normal adult (male) on a normal diet excretes 247 to 494 mgm. of methionine daily.”
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References
Albanese, Frankston and Irby, J. Biol. Chem., 156, 293 (1944).
Saunders, W. B., âœClinical Biochemistryâ (Philadelphia, Pa., 1940).
Dent, Lancet, 637 (Nov. 2, 1946).
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TOMICH, E. Methionine in Urine. Nature 160, 604–605 (1947). https://doi.org/10.1038/160604a0
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DOI: https://doi.org/10.1038/160604a0
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