Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Effects of two marine dietary supplements with high calcium content on calcium metabolism and biochemical marker of bone resorption

European Journal of Clinical Nutrition volume 62, pages 879–884 (2008)Cite this article

Abstract

Background/Objective:

Calcium is essential for the bone metabolism but daily calcium requirements are not met in a significant proportion of the population. Fortunately, oral calcium supplementation can help to meet these needs; however, the calcium bioavailability depends on the calcium sources. The calcium absorption and bioavailability of dietary supplements from marine sources are not known. The objectives of this study were to evaluate the effects of two marine dietary supplements with a high calcium content: a fishbone powder (Phoscalim) and a ray cartilage hydrolysate (Glycollagene), in comparison with milk, and a placebo (maltodextrin), on calcium metabolism and a biochemical marker of bone resorption, using the oral calcium tolerance test.

Subjects:

Twenty male volunteers were randomized to eat 836 mg of calcium from different sources compared to maltodextrin during a Latin square study. Serum calcium concentrations and other parameters of the calcium metabolism, such as serum intact parathyroid hormone (iPTH) and serum C telopeptides (s-CTX), were measured after an acute oral calcium load based on the Pak protocol.

Results:

An increase in serum-corrected calcium areas under the curve (AUC) occurred with Phoscalim and Glycollagene when compared to milk. Significantly lower iPTH concentrations were observed with Glycollagene than with milk at T0+1 h, T0+3 h, T0+6 h and with Phoscalim than with milk at T0+6 h. A significantly lower s-CTX concentration was observed with Glycollagene than with milk and Phoscalim at T0+6 h. Furthermore, the urinary calcium/creatinine ratio increased significantly more with Glycollagen than with milk in T0 h+3 h and T3 h+6 h.

Conclusion: These two dietary supplements from marine sources constitute oral calcium sources when compared to milk on calcium absorption and bone resorption markers on short time.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  • Beck AB, Bugel S, Sturup S, Jensen M, Molgaard C, Hansen M et al. (2003). A novel dual radio and stable isotope method for measuring calcium absorption in human: comparison with the whole body radio isotope retention method. Am J Clin Nutr 77, 399–405.

    Article  CAS  Google Scholar 

  • Dodiuk-Gad RP, Rozen GS, Rennert G, Rennert AS, Ish-shalom S (2005). Sustained effect of short-term calcium supplementation on bone mass in adolescent girls with low calcium intake. Am J Clin Nutr 81, 168–174.

    Article  CAS  Google Scholar 

  • Fardellone P, Bellony R, Brazier M, Dubreuil A, Sebert JL, Maitenaz PC (1993). Etude de la biodisponibilité du calcium: de l'emmental par rapport au bicarbonate de calcium. Cah Nutr Diet 28, 245–249.

    CAS  Google Scholar 

  • Flynn A (2003). The role of dietary calcium in bone health. Proc Nutr Soc 62, 851–858.

    Article  CAS  Google Scholar 

  • Green JH, Booth C, Bunning R (2003). Acute effect of high calcium milk with or without additional magnesium, or calcium phosphate or parathyroid hormone and biochemical markers of bone resorption. Eur J Clin Nutr 57, 61–68.

    Article  CAS  Google Scholar 

  • Gueguen L (1996). Dietary calcium intake in France: contribution of milk and choose. Proceedings of the 1st world Congress on calcium and vitamin D in human life Rome.

  • Gueguen L, Pointillart A (2000). The bioavailability of dietary calcium. J Am Coll Nutr 19 (Suppl), 119S–136S.

    Article  CAS  Google Scholar 

  • Heaney RP, Recker RR, Hinders SM (1988). Variability of calcium absorption. Am J Clin Nutr 47, 262–264.

    Article  CAS  Google Scholar 

  • Heaney RP (2000). Dietary protein and phosphorus do not effect calcium absorption. Am J Clin Nutr 72, 758–761.

    Article  CAS  Google Scholar 

  • Karkkainen MUM, Lamber G, Allargt CJE, Ahonen S, Valimaki M (2001). Does it make a difference low and when you take your calcium ? The acute effects of calcium on calcium and bone metabolism. Am J Clin Nutr 74, 335–342.

    Article  CAS  Google Scholar 

  • Matkovic V, Goel PK, Badenhop-Stevens NE, Landull JD, Li B, Ilich J et al. (2005). Calcium supplementation and bone universal density in females from childhood to young adulthood: a randomised controlled trial. Am J Clin Nutr 81, 175–188.

    Article  CAS  Google Scholar 

  • Martin A (2001). Les apports nutritionnels conseillés pour la population française Tec&Doc (Edit), Paris.

  • Martini L, Wood RJ (2002). Relative bioavailability of calcium rich dietary sources in the elderly. Am J Clin Nutr 76, 1345–1350.

    Article  CAS  Google Scholar 

  • Mortensen L, Charles P (1996). Bioavailability of calcium supplements and the effect of vitamin D: comparisons between milk, calcium carbonate, and calcium carbonat ? vitamin D. Am J Clin Nutr 63, 354–357.

    Article  CAS  Google Scholar 

  • Nicar MJ, Pak CYC (1985). Calcium bioavailability from calcium carbonate and calcium citrate. J Clin Endocrinol Metab 61, 391–393.

    Article  CAS  Google Scholar 

  • Pak CYC, Kaplan R, Bone H, Towser J, Waters O (1975). A simple test for the diagnosis of absorptive, resorptive and renal hypercalciuria. N Engl J Med 292, 497–500.

    Article  CAS  Google Scholar 

  • Qvist P, Christgau S, Pedersen J, Schlemmer A, Christiansen C (2005). Circadian variation in serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting. Bone 31, 57–61.

    Article  Google Scholar 

  • Reginster JY, Denis D, Bartsch V, Deroisy R, Zegels B, Franchimont P (1993). Acute biochemical variations induced by four different calcium salts in healthy male volunteers. Osteoporosis Int 3, 271–275.

    Article  CAS  Google Scholar 

  • Sadideen H, Swaminathan R (2004). Effect of acute oral calcium load on serum PTH and bone resorption in young healthy subjects: an overnight study. Am J Clin Nutr 58, 1161–1165.

    Google Scholar 

  • Schaafsma F (1997). Bioavailability of calcium and magnesium. Eur J Clin Nutr 51 (Suppl), S13–S16.

    PubMed  Google Scholar 

  • Scopacasa F, Whishart JM, Horowitz M, Morris HA, Need AG (2004). Relation between calcium absorption and serum calcitriol in normal men: evidence for age related – intestinal resistance to calcitriol. Eur J Clin Nutr 58, 264–269.

    Article  CAS  Google Scholar 

  • Wolf RL, Cavley JA, Baker CE, Ferrell RE, Charron M, Caggiula AW et al. (2000). Factors associated with calcium absorption efficiency in pre and perimenopausal women. Am J Clin Nutr 72, 466–471.

    Article  CAS  Google Scholar 

  • Zerwekh JE, Sakhae K, Pak CYC (1981). Utility and limitation of calciuric response to oral calcium load as a measure of intestinal calcium absorption, comparison with isotopic fractional calcium absorption. Invest Urol 19, 161–164.

    CAS  PubMed  Google Scholar 

  • Zikan V, Haas T, Stepan JJ (2001). Acute effects in healthy women of oral calcium on the calcium parathyroid axis and bone resorption as assessed by serum β cross-laps. Calcif Tissue Int 68, 352–357.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We are grateful to the nurses of the Centre d'Investigation Clinique de Lille. This work was supported by Centre de Traitement des Produits de la Pêche Copalis (CTPP).

Author information

Authors and Affiliations

  1. Service de nutrition, Institut Pasteur de Lille, Lille, France

    J-M Lecerf, B Boukandoura, A Cayzeele & B Borgiès

  2. Centre d'Investigation Clinique, CH&U-Inserm, Lille, France

    C Lamotte & C Libersa

  3. Centre de Traitement des Produits de la Pêche Copalis, Boulogne sur Mer, France

    C Delannoy

Authors
  1. J-M Lecerf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C Lamotte
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B Boukandoura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Cayzeele
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C Libersa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C Delannoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B Borgiès
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J-M Lecerf.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lecerf, JM., Lamotte, C., Boukandoura, B. et al. Effects of two marine dietary supplements with high calcium content on calcium metabolism and biochemical marker of bone resorption. Eur J Clin Nutr 62, 879–884 (2008). https://doi.org/10.1038/sj.ejcn.1602797

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ejcn.1602797

Keywords

This article is cited by

Search

Advanced search

Quick links