Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Communication
  • Published:

Introduction to the ZENITH study and summary of baseline results

European Journal of Clinical Nutrition volume 59, pages S5–S7 (2005)Cite this article

Abstract

Sponsorship:

The ZENITH Study is supported by the European Commission ‘Quality of Life and Management of Living Resources’ Fifth Framework Program, Contract No: QLK1-CT-2001-00168.

Zinc is known to be essential for a great number of biochemical activities and physiological and cognitive functions. The objective of Zenith study was to investigate the effects of Zn, as a nutritional supplement, on psychological and behavioural factors and on surrogate markers that are indicative of trends towards better health in order to evaluate the need for dietary recommendations specific to the studied population. We report in this paper the summary of baseline results obtained before Zn supplementation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  • Andriollo-Sanchez M, Hininger-Favier I, Meunier N, Toti E, Zaccaria M, Brandollini-Bunlon M, Polito A, O'Connor JM, Ferry M, Coudray C & Roussel AM (2005a): Zinc intake and status in middle-aged and older European subjects. The Zenith study. Eur. J. Clin. Nutr. 59, S37–S41.

    Article  CAS  Google Scholar 

  • Andriollo-Sanchez M, Hininger-Favier I, Meunier N, Venneria E, O'Connor JM, Maiani G, Coudray C & Roussel AM (2005b): Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects. The Zenith study. Eur. J. Clin. Nutr. 59, S58–S62.

    Article  CAS  Google Scholar 

  • Black MM (2003): Micronutrient deficiencies and cognitive functioning. J. Nutr. 133, 3927S–3931S.

    Article  CAS  Google Scholar 

  • Bremner I & Beattie JH (1995): Copper and zinc metabolism in health and disease: speciation and interactions. Proc. Nutr. Soc. 54, 489–499.

    Article  CAS  Google Scholar 

  • Finamore A, Devirgiliis C, Panno D, D'Aquino M, Polito A, Venneria E, Raguzzini A, Coudray C & Mengheri E (2005): Immune response in relation to zinc status, sex and antioxidant defence in Italian elderly population: The ZENITH study. Eur. J. Clin. Nutr. 59, S68–S72.

    Article  CAS  Google Scholar 

  • Heyneman CA (1996): Zinc deficiency and taste disorders. Ann. Pharmacother. 30, 186–187.

    Article  CAS  Google Scholar 

  • Hill T, Meunier N, Andriollo-Sanchez M, Ciarapica D, Hininger-Favier I, Polito A, O'Connor JM, Coudray C & Cashman KD (2005): The relationship between the Zn nutritive status and biochemical markers of bone turnover in older European adults: The ZENITH study. Eur. J. Clin. Nutr. 59, S73–S78.

    Article  CAS  Google Scholar 

  • Hodkinson CF, Kelly M, Coudray C, Gilmore WS, Hannigan BM, O'Connor JM, Strain JJ & Wallace JMW (2005): Zinc status and age-related changes in peripheral blood leukocyte sub-populations in healthy men and women aged 55–70 years: The ZENITH study. Eur. J. Clin. Nutr. 59, S63–S67.

    Article  CAS  Google Scholar 

  • McConville C, Simpson EEA, Rae G, Polito A, Andriollo-Sanchez M, Meunier N, Stewart-Knox BJ, O'Connor JM, Roussel AM, Cuzzolaro M & Coudray C (2005): Positive and negative mood in elderly. The Zenith study. Eur. J. Clin. Nutr. 59, S22–S25.

    Article  CAS  Google Scholar 

  • Paik HY, Joung H, Lee JY, Lee HK, King JC & Keen CL (1999): Serum extracellular superoxide dismutase activity as an indicator of zinc status in humans. Biol. Trace Elem. Res. 69, 45–57.

    Article  CAS  Google Scholar 

  • Schiffman SS (2000): Taste quality and neural coding: implications from psychophysics and neurophysiology. Physiol. Behav. 69, 147–159.

    Article  CAS  Google Scholar 

  • Schiffman SS & Graham BG (2000): Taste and smell perception affect appetite and immunity in the elderly. Eur. J. Clin. Nutr. 54, S54–S63. Review.

    Article  Google Scholar 

  • Shankar AH & Prasad AS (1998): Zinc and immune function: the biological basis of altered resistance to infection. Am. J. Clin. Nutr. 68, 447S–463S.

    Article  CAS  Google Scholar 

  • Simpson EEA, O'Connor JM, Livingstone MBE, Rae G, Stewart-Knox BJ, Andriollo-Sanchez M, Toti E, Meunier N, Ferry M, Polito A & Coudray C (2005a): Health and lifestyle characteristics of older adults. The Zenith study. Eur. J. Clin. Nutr. 59, S13–S21.

    Article  CAS  Google Scholar 

  • Simpson EEA, Maylor E, Rae G, Meunier N, Andriollo-Sanchez M, Catasta G, Mc Conville C, Ferry M, Polito A, Stewart-Knox BJ, Secker D & Coudray C (2005b): Cognitive function in healthy older adults. The Zenith study. Eur. J. Clin. Nutr. 59, S26–S30.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Unité Maladies Métaboliques et Micro-nutriments, INRA de Clermont-Ferrand/Theix, Saint Genès Champanelle, France

    C Coudray

  2. Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, UK

    J M O'Connor & E E A Simpson

  3. Human Nutrition Unit, National Institute for Food and Nutrition Research, Roma, Italy

    G Maiani

  4. Department of Food and Nutritional Sciences, University College, Cork, Ireland

    K D Cashman

  5. Cambridge Cognition Limited, Cambridge, England

    D L Secker

  6. Centre Hospitalier de Valence, Valence, France

    M Ferry

  7. Laboratoire de Nutrition Vieillissement et Maladies Cardiovasculaires, Faculté de Pharmacie, Université de Joseph Fourier, Domaine de la Merci, La Tronche, France

    A M Roussel

Authors
  1. C Coudray
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J M O'Connor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G Maiani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K D Cashman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E E A Simpson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D L Secker
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Ferry
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A M Roussel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C Coudray.

Additional information

Guarantor: C Coudray.

Contributors: CC, AMR, JMO, GM, KDC, DS and MF are the partner's leaders in the different centres of the Zenith study. All authors read and contributed to finalisation of the manuscript.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Coudray, C., O'Connor, J., Maiani, G. et al. Introduction to the ZENITH study and summary of baseline results. Eur J Clin Nutr 59 (Suppl 2), S5–S7 (2005). https://doi.org/10.1038/sj.ejcn.1602304

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ejcn.1602304

Keywords

This article is cited by

Search

Advanced search

Quick links