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A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet

European Journal of Clinical Nutrition volume 59, pages 1142–1148 (2005)Cite this article

Abstract

Objective:

To investigate whether altering energy intake as red meat protein or carbohydrate modifies chylomicron homeostasis and postprandial lipaemia.

Design:

Randomized single-blind dietary intervention trial.

Setting:

School of Public Health, Division of Health Science, Curtin University, Perth, Western Australia.

Subjects:

A total of 20 moderately hypertriglyceridaemic but otherwise healthy subjects were recruited and completed the study.

Intervention:

Participants consumed an isocaloric weight maintenance diet low in protein (14, 53 and 30% of energy as protein, carbohydrate and fat, respectively) or high in protein (25, 35 and 30% energy as protein, carbohydrate and fat) for a period of 6 weeks. Fasting plasma lipids and postprandial lipoprotein studies (triglyceride and apolipoprotein B48) following an oral fat challenge were carried out at the start and conclusion of the dietary intervention period.

Results:

Consumption of the low- or high-protein diet had no significant effect on fasting plasma or postprandial lipaemia, the latter determined as the incremental area under the triglyceride curve following a fat challenge. However, subjects who consumed a low-protein diet for 6 weeks had a substantially exaggerated postprandial chylomicron response, indicated as the area under the apo B48 curve following a fat challenge. The change in postprandial chylomicron kinetics could not be explained by changes in insulin sensitivity, which appeared to be similar before and after intervention with either diet.

Conclusions:

Daily moderate consumption of a lean red meat protein-enriched diet attenuates postprandial chylomicronaemia in response to ingestion of a fatty meal.

Sponsorship:

Meat and Livestock, Australia.

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Acknowledgements

We acknowledge the support of the Meat and Livestock Australia and the Australian Technology Network Centre for Metabolic Fitness.

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Authors and Affiliations

  1. School of Public Health, Australian Technology Network Centre for Metabolic Fitness, Curtin University of Technology, Perth, Australia

    J C L Mamo, A P James, M J Soares, D G Griffiths, K Purcell & J L Schwenke

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  1. J C L Mamo
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  2. A P James
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  3. M J Soares
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  4. D G Griffiths
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Correspondence to J C L Mamo.

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Mamo, J., James, A., Soares, M. et al. A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet. Eur J Clin Nutr 59, 1142–1148 (2005). https://doi.org/10.1038/sj.ejcn.1602224

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