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Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure: a preliminary report

European Journal of Clinical Nutrition volume 52, pages 153–154 (1998)Cite this article

Abstract

Objective: To clarify the influence of insulin therapy on body weight and fat distribution, we compared these parameters in five non-insulin dependent diabetes mellitus (NIDDM) patients, with secondary sulfonylurea failure, before and after insulin therapy. Body weight increased significantly after instituting insulin treatment. However, the visceral to subcutaneous fat (V/S) ratio decreased significantly due to a marked increase in S-fat without a change in V-fat. Insulin therapy necessitated by sulfonylurea failure does not appear to accelerate the atherogenic process in NIDDM patients as there is no increase in visceral fat.

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Authors and Affiliations

  1. Department of Internal Medicine, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, 160, Japan

    I Takei, S Takayama, A Yamauchi, S Nakamoto, Y Kitamura & T Saruta

  2. Department of Sports Medicine Research Center, Keio University School of Medicine, Yokohama, Japan

    F Katsukawa & H Yamazaki

  3. Division of Geriatric Health and Nutrition, National Institute of Health and Nutrition,

    S Inoue

Authors
  1. I Takei
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  2. S Takayama
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  3. A Yamauchi
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  4. S Nakamoto
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  5. Y Kitamura
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  6. F Katsukawa
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  7. H Yamazaki
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  8. T Saruta
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  9. S Inoue
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Takei, I., Takayama, S., Yamauchi, A. et al. Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure: a preliminary report. Eur J Clin Nutr 52, 153–154 (1998). https://doi.org/10.1038/sj.ejcn.1600506

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  • DOI: https://doi.org/10.1038/sj.ejcn.1600506

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