Abstract
JIMENEZ-DIAZ et al.1 have recently reported their failure to induce diabetes in dogs by the intravenous injection of alloxan when both renal pedicles were clamped immediately before and for ten minutes after its administration. They concluded that “the contact between alloxan and the kidney is apparently necessary for the displayof the full diabetogenic effect”. We have repeated these experiments in rabbits and find that alloxan diabetes of the usual degrees of severity is produced when the kidneys are excluded from the circulation by clamping of the renal pedicles.
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References
Jimenez-Diaz, C., Grande-Covian, F., and De Oya, J. C., Nature, 158, 589 (1946).
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DUFF, G., WILSON, D. & McMILLAN, G. The Renal Factor in Alloxan Diabetes. Nature 159, 575–576 (1947). https://doi.org/10.1038/159575a0
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DOI: https://doi.org/10.1038/159575a0
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