Abstract
THE rat is known to synthesize vitamin C in the course of its normal metabolism. It has been observed by Longenecker and associates1 that this synthesis can be greatly stimulated, resulting in the high urinary excretion of the vitamin, when the rats are given daily a variety of compounds, particularly narcotics. In view of the great variation in the nature and constitution of the effective compounds, these authors are inclined to the view that these substances act as promoters rather than precursors for the synthesis of the vitamin. They were not able to suggest, however, any probable mechanism for this biosynthesis of vitamin C by narcotized rats.
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References
Longenecker, H. E., Fricke, H. H., and King, C. G., J. Biol. Chem., 135, 497 (1940).
Quastel, J. H., and Wheatley, A. H. M., Biochem. J., 32, 1936 (1938).
Michaelis, M., and Quastel, J. H., Biochem. J., 35, 518 (1941).
Barron, E. S. G., Lyman, C. M., Lipton, M. A., and Goldinger, J. H., J. Biol. Chem., 141, 957 (1941).
Ball, E. G., Cold Spring Harbor Symposia Quant. Biol., 7, 100 (1939).
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ROY, S., ROY, S. & GUHA, B. Role of Thiamin and Riboflavin in the Biosynthesis of Vitamin C. Nature 158, 238 (1946). https://doi.org/10.1038/158238b0
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DOI: https://doi.org/10.1038/158238b0
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