Abstract
SULPHAPYRIDINE (M and B 693) is readily hydrolysed by dilute mineral acids1. Many isomerides of sulphapyridine have been made and it has been found that the three isomeric derivatives from 3-aminopyridine (3-(o-, m- and p-aminobenzenesulphonamido)pyri-dine) are stable to hot mineral acids. All but one of the derivatives of 2- and 4-aminopyridine which were tested were found to be more or less easily broken down to the corresponding aminopyridine and an aminobenzene sulphonic acid as is shown below: Conditions, sulphonamide refluxed for 30 min. with 15 percent aqueous hydrochloric acid. 2-(o-aminobenzenesulphonamido)pyridine 35 percent unchanged 2-(p-aminobenzenesulphonamido)pyridine Complete hydrolysis. 4-(p-aminobenzenesulphonamido)pyridine Complete hydrolysis.
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Phillips, J. Chem. Soc, 9 (1941).
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PHILLIPS, M. Acid Hydrolysis of Sulphapyridines. Nature 157, 265 (1946). https://doi.org/10.1038/157265b0
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DOI: https://doi.org/10.1038/157265b0
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