Abstract
YET another new series of compounds has been added to the growing list of antiseptics. Prof. J. Mclntosh and his collaborators (Lancet of July 28, p. 97) report upon their trials of 'Flavazole', which is a chemical combination, in equimolecular proportions, of sulphathiazole and proflavine base. This represents a new type of acridine compound, which has been introduced by the research laboratories of Messrs. Boots Pure Drug Co., Ltd., and it is claimed to be an advance on the mixtures of one part of proflavine and 99 parts of sulphathiazole, widely used in powder form in the Army and in industry for the first-aid treatment of wounds. These new compounds are neutral or slightly alkaline in solution and are less irritant than their acridine components. In vitro tests have shown that they “have lost none of the bacteriostatic powers of their components”. Comparison of the action of 'Flavazole', sulphathiazole and proflavine upon “all types of organisms likely to be found in wounds”(including the Clostridia which cause gas gangrene) shows that the bacteriostatic power of 'Flavazole' is greater than that of either of its components, especially against Gram-negative bacilli. It has slightly more activity against Pseudo-monas pyocyanea and Proteus.
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'Flavazole', an Effective New Antiseptic. Nature 157, 223 (1946). https://doi.org/10.1038/157223c0
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DOI: https://doi.org/10.1038/157223c0