Abstract
KNOWLEDGE of the reaction mechanism of different substances with intracellular enzymes or catalytic systems involved in the metabolism, growth and multiplication of cells is of fundamental importance in the study of the pharmacological action of drugs and of chemotherapy. Cells are, however, not equally permeable to substances which may react with intracellular catalysts, whether as metabolites, activators or inhibitors. As the rates at which such reactions may take place are often controlled by the permeability of cells to these substances, the study of the mechanism of cell permeability becomes of considerable theoretical and practical importance.
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KEILIN, D., HARTREE, E. SPECTROSCOPIC STUDY OF THE PERMEABILITY AND LYSIS OF RED BLOOD CORPUSCLES. Nature 157, 210–213 (1946). https://doi.org/10.1038/157210a0
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DOI: https://doi.org/10.1038/157210a0
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