Abstract
Race1 and Wiener2 described in 1944 independently a peculiar phenomenon concerning the Rh agglutination. When Rh+ red blood corpuscles were incubated with some sera which did not agglutinate them, a further incubation with potent anti-Rh sera failed to produce an agglutination of these cells. Race called the antibody present in such sera the 'coating' or 'incomplete' antibody; Wiener designated the test as a 'blocking' test and called it the "counterpart of the inhibition test for haptens and group-specific substances". Wiener as well as Race and Taylor3 stressed the fact that by means of this test isoimmunization can be detected in Rh- women when ordinary agglutination tests fail to give such evidence.
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References
Race, R. R., Nature, 153, 771 (1944).
Wiener, A. S., Proc. Soc. Exp. Biol. and Med., 56, 173 (1944).
Race, R. R., and Taylor, G. L., Brit. Med. J., 756 (1944).
Boorman, K. E., Dodd, B. E., and Mollison, P. L., Brit. Med. J., ii, 535, 569 (1942).
Baar, H. S., Queen's Mag., 36, 48 (1943).
Landsteiner, K., "The Specificity of Serological Reactions", (Springfield and Baltimore: Charles C. Thomas.)
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BAAR, H. The Race – Wiener Test in Hæmolytic Disease of the New-born. Nature 155, 789–790 (1945). https://doi.org/10.1038/155789a0
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DOI: https://doi.org/10.1038/155789a0
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