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Action of Penicillin on the Rate of Fall in Numbers of Bacteria in vivo

Abstract

DURING work on the use of penicillin pastilles in oral infections, of which a preliminary report has been published1, numerous experiments have been undertaken in order to determine the total and differential fall in numbers of different species of bacteria in the mouth and the rate of this fall, under the influence of penicillin. This rate of fall is of particular interest, and as it appears that certain deductions on the mode of action of penicillin can be drawn from the experiments, it is considered that it is worth directing attention to them in a separate publication. The technique of determining the rate of fall was as follows:

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  1. MacGregor and Long, Brit. Med. J., ii, 686 (1944).

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MACGREGOR, A., LONG, D. Action of Penicillin on the Rate of Fall in Numbers of Bacteria in vivo. Nature 155, 201–202 (1945). https://doi.org/10.1038/155201a0

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