Abstract
IT has been found that the urinary excretion of mepacrine has a relation to the excretion of ammonia. The simplest description of this empirical relation is that the mepacrine clearance from the plasma is directly proportional to the rate of excretion of ammonia. This may be expressed thus:
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Masen, J. M., J. Biol. Chem., 148, 529 (1943).
Haag, H. B., Larson, P. S., and Schwartz, J. J., J. Pharm. Exp. Ther., 79, 136 (1943).
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MAEGRAITH, B., PARSONS, D., BROWN, G. et al. Ammonia Excretion and the Clearance of Mepacrine. Nature 154, 766 (1944). https://doi.org/10.1038/154766a0
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DOI: https://doi.org/10.1038/154766a0
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