Abstract
THE suggestion that thyroxine might be formed in Nature from tyrosine through the stage of diiodotyrosine was made at an early stage of the elucidation of the chemistry of thyroxine, and was made more probable when the constitution of the latter was finally determined. Over a number of years several pieces of evidence, all indirect in character, Were brought forward in support of this biogenetic hypothesis, which thus came to be generally accepted.
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Thyroxine: Its Biosynthesis and Its Immuno-Chemistry*. Nature 154, 122–123 (1944). https://doi.org/10.1038/154122b0
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DOI: https://doi.org/10.1038/154122b0