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ORIGIN OF MALIGNANT TUMOUR CELLS

Nature volume 151, pages 244–246 (1943)Cite this article

Abstract

IN the light of recent knowledge of chromosome chemistry and gene action and its bearing on the interpretation of the mitotic cycle in the cell, a cytological analysis was carried out on 565 human tumours (carcinoma of the skin, œsophagus, colon, rectum, larynx, lung, cervix, uterus and breast)1. It was expected that by analysing the characteristics of chromosome and nucleolus behaviour, abnormalities specific to the internal organization of tumour cells might be detected. The present article contains a brief summary of the data obtained2.

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References

  1. The cytological analysis was made possible by the financial support of the British Empire Cancer Campaign, and by the generous help of the Holt. Radium Institute, Manchester.

  2. A more detailed description will be given elsewhere.

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  15. Dr. T. Caspersson, using cytochemical methods, arrived at the same conclusion. His data indicate that "the heterochromatic section of the nucleus must play a very specific role in carcinogenesis" (personal communication).

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Authors and Affiliations

  1. Institute of Genetics, University of Edinburgh,

    P. C. KOLLER

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  1. P. C. KOLLER
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KOLLER, P. ORIGIN OF MALIGNANT TUMOUR CELLS. Nature 151, 244–246 (1943). https://doi.org/10.1038/151244a0

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