Abstract
LIPMANN1 found that, although adenylic acid does not influence the rate of oxidative decarboxylation of pyruvic acid by preparations of lactic acid bacteria, it is phosphorylatedto adenosine-polyphosphate. With brain dispersions it has been shown in this laboratory2 that oxidation of pyruvate requires the presence of both inorganic phosphate3 and adenine nucleotide (adenylic acid, adenosine-triphosphate). These observations suggested that a cycle of phosphorylation is involved in the enzymatic oxidation of pyruvate.
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Banga, Ochoa and Peters, NATURE, 144, 74 (1939); Biochem. J., 33, 1980 (1939).
cf. Lipmann, Enzymologia, 4, 65 (1937) as regards bacteria.
Ostern, Guthke and Terszakowec, Z. physiol. Chem., 243, 9 (1936).
Ochoa, NATURE, 144, 834 (1939).
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OCHOA, S. “Coupling” of Phosphorylation with Oxidation of Pyruvic Acid in Brain Tissue. Nature 145, 747 (1940). https://doi.org/10.1038/145747a0
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DOI: https://doi.org/10.1038/145747a0
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