Abstract
WE recently described1 the catalytic properties of a flavoprotein isolated from heart. At that time we were unable to observe the reduction of flavoprotein by reduced coenzyme I. We now find that, by eliminating coloured impurities in the various components of the catalytic system, the rapid reduction of flavoprotein to its leuco form can be readily demonstrated. Under the conditions of our experiment, the leuco form is non-autoxidizable but can be oxidized by arriers such as methylene blue. The mechanism of the catalytic effect of heart flavoprotein involves a cycle of reduction by reduced coenzyme I and oxidation of the leuco form by some suitable carrier.
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Straub, Corran and Green, NATURE, 143, 119 (1939).
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STRAUB, F., CORRAN, H. & GREEN, D. Reduction of Heart Flavoprotein. Nature 143, 334 (1939). https://doi.org/10.1038/143334a0
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DOI: https://doi.org/10.1038/143334a0
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